System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy

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System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy.

We applied cardiovascular system identification (CSI) to characterize closed-loop cardiovascular regulation in patients with diabetic autonomic neuropathy (DAN). The CSI method quantitatively analyzes beat-to-beat fluctuations in noninvasively measured heart rate, arterial blood pressure (ABP), and instantaneous lung volume (ILV) to characterize four physiological coupling mechanisms, two of wh...

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Diabetic cardiovascular autonomic neuropathy.

One of the most overlooked of all serious complications of diabetes is cardiovascular autonomic neuropathy (CAN),1–3 which encompasses damage to the autonomic nerve fibers that innervate the heart and blood vessels, resulting in abnormalities in heart rate control and vascular dynamics.4 The present report discusses the clinical manifestations (eg, resting tachycardia, orthostasis, exercise int...

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Noninvasive Assessment and Modeling of Diabetic Cardiovascular Autonomic Neuropathy

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Diabetic autonomic neuropathy.

Diabetic autonomic neuropathy is the most common and troublesome complication of diabetes mellitus. Although involvement of the autonomic nervous system is generally diffuse, symptoms may be confined to a single target organ or organ system. Complications of diabetic autonomic neuropathy contribute greatly to the morbidity, mortality, and reduced quality of life of the person with diabetes and ...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

سال: 1999

ISSN: 0363-6119,1522-1490

DOI: 10.1152/ajpregu.1999.276.3.r905